作者:封加涛,苏艳玲,龚光甫,胡冬煦,曹亚
【关键词】 心脏缺损,先天性;高血压,肺性;一氧化氮合酶;RNA,信使
【Abstract】 AIM: To explore the pathophysiological significance of nitric oxide(NO) and nitric oxide synthase(NOS) in congenital heart defects with pulmonary hypertension. METHODS: Twentyfour patients with congenital heart defects were divided into 3 groups: mild pulmonary hypertension group(n=8), moderate or severe pulmonary hypertension group(n=9), and nonpulmonary hypertension group(n=7). NOS mRNA expression was detected in lung tissues with reverse transcriptase polymerase chain reaction (RTPCR). RESULTS: The NOS mRNA expression levels in the patients with moderate or severe pulmonary hypertension were much lower than those in the ones with mildpulmonary hypertension or nonpulmonary hypertension (P
先天性心脏病合并肺动脉高压一氧化氮合酶mRNA表达及临床意义
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